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Peptides act on cell receptors to induce prompt hormonal cascades with much more receptor specificity than many systemic treatments, allowing for targeted effects and faster onset

Phase I Trial: D+Q in Early Alzheimers Disease, SToMP-AD The primary objective of the vanguard SToMP-AD trial was to evaluate CNS penetrance of D and Q and collect data relevant to safety of intermittent orally delivered senolytic therapy

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doi:10.1016/S0014-2999(96)00795-9 42

The lower dose (100 mg vs 500 mg in standard reduced products) reflects the theoretically higher bioavailability of the acetylated form